Sabine Leske

Solbakk, Anne-Kristin; Lubell, James; Leske, Sabine; Funderud, Ingrid; Anais, Llorens; Blenkmann, Alejandro Omar; Foldal, Maja Dyhre; Meling, Torstein R.; Knight, Robert T. & Endestad, Tor (2021). Monitoring of self-paced action timing and sensory outcomes after lesions to the orbitofrontal cortex. Journal of Cognitive Neuroscience. 

Llorens, Ana?s; Funderud, Ingrid; Blenkmann, Alejandro Omar; Lubell, James; Foldal, Maja Dyhre; Leske, Sabine Liliana; Huster, Rene; Meling, Torstein Ragnar; Knight, Robert T; Solbakk, Anne-Kristin & Endestad, Tor (2020). Preservation of Interference Effects in Working Memory After Orbitofrontal Damage. Frontiers in Human Neuroscience.

Leske, S., Dalal, S.S. (2019). Reducing power line noise in EEG and MEG data via spectrum interpolation. NeuroImage. 

Frey, J.N., Ruhnau, P., Leske, S., Siegel, M., Braun, C. and Weisz, N. (2016). The Tactile Window to Consciousness is Characterized by Frequency-Specific Integration and Segregation of the Primary Somatosensory Cortex. Scientific Reports.

Leske, S., Ruhnau, P., Frey, J., Lithari, C., M¨¹ller, N., Hartmann, T. and Weisz, N. (2015). Prestimulus Network Intergration of Auditory Cortex Predisposes Near-Threshold Perception Independently of Local Excitability. Cerebral Cortex. 

Hauswald, A., ?belacker, T., Leske, S., Weisz, N. (2015). What it means to be Zen: Marked modulations of local and interareal synchronization during open monitoring meditation. NeuroImage. 

Leske, S., Tse, A., Oosterhof, N., Hartmann, T., M¨¹ller, N., Keil, J. and Weisz, N. (2014). The strength of alpha and beta oscillations parametrically scale with the strength of an illusory auditory percept. NeuroImage. 

M¨¹ller, N., Leske, S., Hartmann, T., Szebeny, S. and Weisz, N. (2014). Listen to yourself: The medial prefrontal cortex modulates auditory alpha power during speech preparation. Cerebral Cortex. 

Weisz, N., M¨¹ller, N., Jatzev, S., & Bertrand, O. (2014). Oscillatory alpha modulations in right auditory regions reflect validity of acoustic cues in an auditory spatial attention task. Cerebral Cortex. 

Zander, T.O., Lehne, M. Ihme, K., Jatzev, S., Correia, J., Kothe, C., Picht, B., Nijboer, F. (2012). A dry EEG-system for scientific research and brain-computer interfaces. Frontiers in Neuroprosthetics.

Zander, T. O., Jatzev, S. (2012). Context-aware brain-computer interfaces: Exploring the information space of user, technical system and environment. Journal of Neural Engineering. 

Book chapters
Zander, T.O., Kothe, C., Jatzev, S., Gaertner, M. (2010). Enhancing Human-Computer Interaction with input from active and passive Brain-Computer Interfaces. In Tan, Nijholt (Eds.): (B+H)CI: The Human in Brain-Computer Interfaces and the Brain in Human-Computer Interactions.

• Blenkmann, Alejandro Omar; Leske, Sabine Liliana; Anais, Llorens; Lin, Jack J.; Chang, Edward F. & Brunner, Peter [Vis alle 12 forfattere av denne artikkelen] (2024). Anatomical registration of intracranial electrodes. Robust model-based localization and deformable smooth brain-shift compensation methods. Journal of Neuroscience Methods. ISSN 0165-0270. 404. doi: 10.1016/j.jneumeth.2024.110056.
• Asko, Olgerta; Blenkmann, Alejandro Omar; Leske, Sabine Liliana; Foldal, Maja Dyhre; Anais, Llorens & Funderud, Ingrid [Vis alle 10 forfattere av denne artikkelen] (2024). Altered hierarchical auditory predictive processing after lesions to the orbitofrontal cortex. eLIFE. ISSN 2050-084X. 13. doi: 10.7554/eLife.86386.
• Weber, Jan; Solbakk, Anne-Kristin; Blenkmann, Alejandro Omar; Anais, Llorens; Funderud, Ingrid & Leske, Sabine Liliana [Vis alle 11 forfattere av denne artikkelen] (2024). Ramping dynamics and theta oscillations reflect dissociable signatures during rule-guided human behavior. Nature Communications. ISSN 2041-1723. 15(1). doi: 10.1038/s41467-023-44571-7.
• Leske, Henning; Camenisch Gross, Ulrike; Hofer, Silvia; Neidert, Marian Christoph; Leske, Sabine Liliana & Weller, Michael [Vis alle 8 forfattere av denne artikkelen] (2023). MGMT methylation pattern of long-term and short-term survivors of glioblastoma reveals CpGs of the enhancer region to be of high prognostic value. Acta neuropathologica communications. ISSN 2051-5960. 11:139(1), s. 1¨C12. doi: 10.1186/s40478-023-01622-w. Fulltekst i vitenarkiv
• Foldal, Maja Dyhre; Leske, Sabine Liliana; Blenkmann, Alejandro Omar; Endestad, Tor & Solbakk, Anne-Kristin (2022). Attentional modulation of beta-power aligns with the timing of behaviorally relevant rhythmic sounds. Cerebral Cortex. ISSN 1047-3211. 33(5), s. 1876¨C1894. doi: 10.1093/cercor/bhac179.
• Solbakk, Anne-Kristin; Lubell, James; Leske, Sabine; Funderud, Ingrid; Anais, Llorens & Blenkmann, Alejandro Omar [Vis alle 10 forfattere av denne artikkelen] (2021). Monitoring of self-paced action timing and sensory outcomes after lesions to the orbitofrontal cortex. Journal of Cognitive Neuroscience. ISSN 0898-929X. 33(9), s. 1956¨C1975. doi: 10.1162/jocn_a_01733.
• Llorens, Ana?s; Funderud, Ingrid; Blenkmann, Alejandro Omar; Lubell, James; Foldal, Maja Dyhre & Leske, Sabine Liliana [Vis alle 11 forfattere av denne artikkelen] (2020). Preservation of Interference Effects in Working Memory After Orbitofrontal Damage. Frontiers in Human Neuroscience. ISSN 1662-5161. 13, s. 1¨C15. doi: 10.3389/fnhum.2019.00445. Fulltekst i vitenarkiv Vis sammendrag

  Orbitofrontal cortex (OFC) is implicated in multiple cognitive processes, including inhibitory control, context memory, recency judgment, and choice behavior. Despite an emerging understanding of the role of OFC in memory and executive control, its necessity for core working memory (WM) operations remains undefined. Here, we assessed the impact of OFC damage on interference effects in WM using a Recent Probes task based on the Sternberg item-recognition task (1966). Subjects were asked to memorize a set of letters and then indicate whether a probe letter was presented in a particular set. Four conditions were created according to the forthcoming response ("yes"/"no") and the recency of the probe (presented in the previous trial set or not). We compared behavioral and electroencephalography (EEG) responses between healthy subjects (n = 14) and patients with bilateral OFC damage (n = 14). Both groups had the same recency pattern of slower reaction time (RT) when the probe was presented in the previous trial but not in the current one, reflecting the proactive interference (PI). The within-group electrophysiological results showed no condition difference during letter encoding and maintenance. In contrast, event-related potentials (ERPs) to probes showed distinct within-group condition effects, and condition by group effects. The response and recency effects for controls occurred within the same time window (300-500 ms after probe onset) and were observed in two distinct spatial groups including right centro-posterior and left frontal electrodes. Both clusters showed ERP differences elicited by the response effect, and one cluster was also sensitive to the recency manipulation. Condition differences for the OFC group involved two different clusters, encompassing only left hemisphere electrodes and occurring during two consecutive time windows (345-463 ms and 565-710 ms). Both clusters were sensitive to the response effect, but no recency effect was found despite the behavioral recency effect. Although the groups had different electrophysiological responses, the maintenance of letters in WM, the evaluation of the context of the probe, and the decision to accept or reject a probed letter were preserved in OFC patients. The results suggest that neural reorganization may contribute to intact recency judgment and response after OFC damage.

• Leske, Sabine & Dalal, Sarang S. (2019). Reducing power line noise in EEG and MEG data via spectrum interpolation. NeuroImage. ISSN 1053-8119. 189, s. 763¨C776. doi: 10.1016/j.neuroimage.2019.01.026. Fulltekst i vitenarkiv

Se alle arbeider i Cristin

• Solli, Sandra; Danielsen, Anne; Leske, Sabine Liliana; Blenkmann, Alejandro Omar; Doelling, Keith & Solbakk, Anne-Kristin [Vis alle 7 forfattere av denne artikkelen] (2024). Rhythm-based temporal expectations: Unique contributions of predictability and periodicity. Vis sammendrag

  Flexibly adapting to our dynamic surroundings requires anticipating upcoming events and focusing our attention accordingly. Rhythmic patterns of sensory input offer valuable cues for these temporal expectations and facilitate perceptual processing. However, a gap in understanding persists regarding how rhythms outside of periodic structures influence perception. Our study aimed to delineate the distinct roles of predictability and periodicity in rhythm-based expectations. Participants completed a pitch-identification task preceded by different rhythm types: periodic predictable, aperiodic predictable, and aperiodic unpredictable. By manipulating the timing of the target sound, we observed how auditory sensitivity was modulated by the target position in the different rhythm conditions. The results revealed a clear behavioral benefit of predictable rhythms, regardless of their periodicity. Interestingly, we also observed an additional effect of periodicity. While both periodic and aperiodic predictable rhythms improved overall sensitivity, only the periodic rhythm seemed to induce an entrained sensitivity pattern, wherein sensitivity peaked in synchrony with the expected continuation of the rhythm. The recorded event-related brain potentials further supported these findings. The target-evoked P3b, possibly a neural marker of attention allocation, mirrored the sensitivity patterns. This supports our hypothesis that perceptual sensitivity is modulated by temporal attention guided by rhythm-based expectations. Furthermore, the effect of rhythm predictability seems to operate through climbing neural activity (similar to the CNV), reflecting preparation for the target. The effect of periodicity is likely related to more precise temporal expectations and could possibly involve neural entrainment. Our findings suggest that predictability and periodicity influence perception via distinct mechanisms.

• Volehaugen, Vegard Akselsson; Leske, Sabine Liliana; Funderud, Ingerid; Rezende Carvalho, Vinicius; Endestad, Tor & Solbakk, Anne-Kristin [Vis alle 7 forfattere av denne artikkelen] (2024). Unheard Surprises: Attention-Dependent Neocortical Dynamics Following Unexpected Omissions Revealed by Intracranial EEG.
• Asko, Olgerta; Volehaugen, Vegard Akselsson; Leske, Sabine Liliana; Funderud, Ingrid; Llorens, Ana?s & Ivanovic, Jugoslav [Vis alle 12 forfattere av denne artikkelen] (2024). Predictive encoding of deviant tone sequences in the human prefrontal cortex.
• Asko, Olgerta; Volehaugen, Vegard Akselsson; Leske, Sabine Liliana; Funderud, Ingrid; Anais, Llorens & Ivanovic, Jugoslav [Vis alle 12 forfattere av denne artikkelen] (2024). Predictive encoding of deviant tone sequences in the human prefrontal cortex. Vis sammendrag

  The ability to use predictive information to guide perception and action relies heavily on the prefrontal cortex (PFC), yet the involvement of its subregions in predictive processes remains unclear. Recent perspectives propose that the orbitofrontal cortex (OFC) generates predictions about perceptual events, actions, and their outcomes while the lateral prefrontal cortex (LPFC) is involved in prospective functions, which support predictive processes, such as selective attention, working memory, response preparation or inhibition. To further delineate the roles of these PFC areas in predictive processing, we investigated whether lesions would impair the ability to build predictions of future events and detect deviations from expected regularities. We used an auditory deviance detection task, in which the structural regularities of played tones were controlled at two hierarchical levels by rules defined at a local (i.e., between tones within sequences) and global (i.e., between sequences) level. We have recently shown that OFC lesions affect detecting prediction violations at two hierarchical levels of rule abstraction, i.e., altered MMN and P3a to local and simultaneous local + global prediction violations (https://doi.org/10.7554/eLife.86386). Now, we focus on the task's predictive aspect and present the latest results showing the involvement of PFC subregions in anticipation of deviances informed by implicit predictive information. Behavioral data shows that deviance expectancy induced faster deviance detection in healthy adults (n=22), suggesting that participants track a state space representation of the task and anticipate upcoming deviant sequences. The analysis of EEG data from patients with focal lesions to the OFC (n = 12) or LPFC (n = 10), and SEEG from the same areas in patients with epilepsy (n = 7), revealed interesting differences. Healthy adults (n = 15) showed modulations of the Contingent Negative Variation (CNV) ¨C a marker of anticipatory activity - tracking the expectancy of deviant tone sequences. However, patients with OFC lesions lacked CNV sensitivity to the predictive context, while patients with LPFC lesions showed moderate sensitivity compared to healthy adults. These results were further supported by intracranial recordings, which revealed expectancy modulation of the high-frequency broadband signal from electrodes in OFC and LPFC, with an earlier latency of activity modulation for the OFC and a later one for the LPFC. Altogether, the complementary approach from behavioral, intracerebral EEG, scalp EEG, and causal lesion data provides compelling evidence for the distinct engagement of the two prefrontal areas in predicting future events and signaling deviations.

• Solbakk, Anne-Kristin; Hope, Mikael; Solli, Sandra; Leske, Sabine Liliana; Foldal, Maja Dyhre & Blenkmann, Alejandro Omar (2024). Research seminar .
• Solli, Sandra; Danielsen, Anne; Leske, Sabine Liliana; Blenkmann, Alejandro Omar; Doelling, Keith & Solbakk, Anne-Kristin [Vis alle 7 forfattere av denne artikkelen] (2024). Rhythm-based temporal expectations: Unique contributions of predictability and periodicity.
• Grane, Venke Arntsberg; Endestad, Tor; St?ver, Isak Elling August; Leske, Sabine Liliana & Solbakk, Anne-Kristin (2024). Executive Function in a Treatment-Naive ADHD Cohort Diagnosed in Adulthood . Vis sammendrag

  Background: Attention Deficit Hyperactivity Disorder (ADHD) is an early onset neurodevelopmental condition presenting with diverse cognitive/behavioral impairments that persist into adulthood for half of those affected. Objective: To examine whether unmedicated adults show general- or specific reductions in core executive functions (EFs). Method: Performance on EF-tasks was assessed in adult patients with ADHD, Combined type (n=36) and in healthy controls (n=34), matched on gender, age, and education level. The tasks tapped memory span/working memory (Digit Span), interference control/response inhibition (Color Word Interference Test; CWIT-Inhibition), set-shifting/switching (CWIT-Switching; Trail Making Test [TMT]), and abstract reasoning (Wisconsin Card Sorting Test; [WCST]). Results: There was no group difference in immediate memory span, but the patients performed significantly worse than controls when there was an additional demand on working memory. Statistically controlling for individual differences in information processing speed (using an independent reaction time measure) did not alter the result. Patients performed inferiorly on basic psychomotor speed conditions of the TMT, but the most pronounced group difference appeared on the set-shifting condition. The CWIT-Inhibition condition did not distinguish the groups, but patients had a near-significant tendency to perform more poorly when a concurrent demand on rapid set-switching was introduced. They completed fewer card-sorting categories on the WCST than controls, with more errors overall. There was no significant difference in perseverative errors, but patients committed more non- perseverative errors and failures to maintain set, indicating more random choices and/or losing track of the current sorting principle. Conclusion: ADHD-related reductions of attention maintenance, switching, and working memory, but not inhibitory control, support the literature indicating that ADHD in adulthood is neither associated with specific deficits in inhibitory control, and nor with a general executive impairment. Accordingly, clinical assessment should span a range of EF tests, including the core control functions studied here.

• Leske, Sabine Liliana; St?ver, Isak Elling August; Solbakk, Anne-Kristin; Endestad, Tor; Kam, Julia & Grane, Venke Arntsberg (2024). Behavioral and Electrophysiological Markers of Altered Mind Wandering and Sustained Attention in Adult ADHD . Vis sammendrag

  Background: Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder that often persists into adulthood. Difficulties with executive control and sustained attention are key characteristics of the disorder that often lead to thoughts that are unrelated to the current task, i.e., mind wandering. Objective: Investigate behavioral and neurophysiological correlates of sustained attention and mind wandering in adults with ADHD not on medication when examined. Method: Sustained attention and propensity to mind-wander was investigated in ADHD patients (n=17) and in healthy controls (n=17), matched on gender, age, and IQ. Participants performed an auditory oddball task (participant feedback: On or Off Task), which required continuous manual responses to standard and target tones, while Electroencephalography (EEG) was measured. Sustained attentional control was additionally examined with the Test of Variables of Attention (T.O.V.A.). General IQ was estimated with a reduced version of the Wechsler Adult Intelligence Scale, 4th edition (WAIS-IV). Results: ADHD patients reported significantly more episodes of mind wandering (Off Task), exhibited reduced target detection accuracy and more Off Task impulsive responses compared to controls. Patients showed a significantly reduced P300 for the target-standard difference components, for both On and Off Task conditions. This target-standard P300 difference was less modulated between On versus Off Task conditions in patients compared to controls. In the T.O.V.A. test, patients committed significantly more Commission Errors, but did not differ from controls on other variables (Attention Comparison score, Reaction Time variability and latency, Omission Errors). Conclusion: In comparison to controls, patients showed deteriorated behavioral performance, more episodes of mind wandering, and reduced P300 in a sustained attention task. The P300 decrease likely reflects impaired control of attentional resources allocated to the task, which has an impact on high-level cognitive processing abilities, while early sensory-related stimulus processing is intact.

• Leske, Sabine Liliana; Endestad, Tor; Volehaugen, Vegard Akselsson; Foldal, Maja Dyhre; Blenkmann, Alejandro Omar & Solbakk, Anne-Kristin [Vis alle 7 forfattere av denne artikkelen] (2024). Predicting the Beat Bin: Beta Oscillations Predict the Envelope Sharpness in a Rhythmic Sequence .
• Blenkmann, Alejandro Omar; Volehaugen, Vegard Akselsson; Rezende Carvalho, Vinicius; Leske, Sabine Liliana; Llorens, Anais & Funderud, Ingrid [Vis alle 14 forfattere av denne artikkelen] (2024). An intracranial EEG study on auditory deviance detection.
• Blenkmann, Alejandro Omar; Leske, Sabine Liliana; Llorens, Anais; Lin, Jack J.; Chang, Edward & Brunner, Peter [Vis alle 12 forfattere av denne artikkelen] (2024). Anatomical registration of intracranial electrodes.
• Bonetti, Leonardo; Foldal, Maja Dyhre; Leske, Sabine Liliana; Asko, Olgerta; Volehaugen, Vegard Akselsson & Solli, Sandra [Vis alle 7 forfattere av denne artikkelen] (2023). Auditory perception, memory, and predictions .
• Blenkmann, Alejandro Omar; Asko, Olgerta; Volehaugen, Vegard; Foldal, Maja Dyhre; Solli, Sandra & Leske, Sabine Liliana [Vis alle 9 forfattere av denne artikkelen] (2023). Auditory perception, memory, and predictions.
• Volehaugen, Vegard; Leske, Sabine Liliana; Funderud, Ingrid; Llorens, Ana?s; Carvalho, Vinicius Rezende & Endestad, Tor [Vis alle 8 forfattere av denne artikkelen] (2023). Echoes of the unheard: An intracranial electrophysiology study of expectation and attention in auditory omission processing.
• Blenkmann, Alejandro Omar; Solbakk, Anne-Kristin; Leske, Sabine Liliana; Llorens, Ana?s; Funderud, Ingrid & Larsson, P?l Gunnar [Vis alle 10 forfattere av denne artikkelen] (2023). Temporal and precentral brain activity in automatic auditory deviance detection. Evidence from human intracranial EEG recordings.
• Asko, Olgerta; Solbakk, Anne-Kristin; Leske, Sabine Liliana; Meling, Torstein Ragnar; Knight, Robert T. & Endestad, Tor [Vis alle 7 forfattere av denne artikkelen] (2023). The orbitofrontal cortex (OFC) has a critical role in the generation of high-level expectations.
• Solli, Sandra; Doelling, Keith; Leske, Sabine Liliana; Danielsen, Anne & Endestad, Tor (2023). The role of the motor system in predicting accelerating and decelerating auditory rhythms.
• Solli, Sandra; Danielsen, Anne; Leske, Sabine Liliana; Solbakk, Anne-Kristin & Endestad, Tor (2023). Periodic vs Aperiodic Temporal Predictions: Shared or Separate Mechanisms?
• Solli, Sandra; Danielsen, Anne; Leske, Sabine Liliana; Blenkmann, Alejandro Omar; Solbakk, Anne-Kristin & Endestad, Tor (2023). Both periodic and aperiodic rhythms facilitate perceptual processing.
• Solli, Sandra; Danielsen, Anne; Leske, Sabine Liliana; Blenkmann, Alejandro Omar; Solbakk, Anne-Kristin & Endestad, Tor (2023). Periodic vs Aperiodic Temporal Predictions: Shared or Separate Mechanisms? .
• Leske, Sabine Liliana; Endestad, Tor; Volehaugen, Vegard; Foldal, Maja Dyhre; Blenkmann, Alejandro Omar & Solbakk, Anne-Kristin [Vis alle 7 forfattere av denne artikkelen] (2023). Predicting the Beat Bin ¨C Beta Oscillations Support Top-Down Prediction of The Temporal Precision of a Beat .
• Asko, Olgerta; Solbakk, Anne-Kristin; Leske, Sabine Liliana; Meling, Torstein Ragnar; Knight, Robert T. & Endestad, Tor [Vis alle 7 forfattere av denne artikkelen] (2023). Orbitofrontal lesion impacts formation of auditory expectations. Vis sammendrag

  Current findings of orbitofrontal cortex (OFC) function suggest that this region might have a role in the generation of prediction error signals associated with top-down expectation of upcoming stimuli. We investigated the impact of lesions to the OFC on the Contingent Negative Variation (CNV), an electrophysiological marker of cognitive expectation and time perception. Twelve OFC patients and fifteen healthy controls performed an auditory local-global paradigm while brain electrical activity was recorded. The structural regularities of the tones were controlled at two hierarchical levels by rules defined at a local (i.e., between tones within sequences) level with a short timescale and at a global (i.e., between sequences) level with a longer timescale. At the global level, deviant tone sequences were interspersed among standard tone sequences in a pseudorandom order, rendering some deviant sequences more anticipated than others. We found that healthy controls exhibited CNV build-up before the occurrence of deviant sequences. The CNV drift rate was modulated by the expectancy of deviant sequences (i.e., the higher the expectancy, the higher the CNV drift rate), reflecting their ability to anticipate when a deviant tone sequence would occur. However, patients with OFC lesions did not show CNV drift modulations by the expectancy of the deviant tone sequences, indicating impaired anticipation of these upcoming events. These findings suggest involvement of the OFC in generating auditory expectations based on the contextual and temporal structure of the task.

• Solbakk, Anne-Kristin; Blenkmann, Alejandro Omar; Leske, Sabine Liliana & Endestad, Tor (2023). Orbitofrontal lesion impacts formation of auditory expectations.
• Leske, Sabine Liliana (2022). Phase Amplitude Coupling (PAC). Vis sammendrag

  An introduction to the Phase Amplitude Coupling (PAC) measure and how it is applied to EEG data (example code in MATLAB). The caveats of the measure are covered and which sanity checks might be necessary.

• Leske, Sabine Liliana (2022). Fourier Transform. Vis sammendrag

  An introduction to the Fourier transform and how it is applied to EEG data. The short time fourier transform (STFT) and different measures (phase and amplitude) derived from it are explained.

• Leske, Sabine Liliana (2022). Inter-Trial Coherence (ITC). Vis sammendrag

  An introduction to the inter-trial coherence measure (ITC) and how it is applied to EEG data (with example code/scripts in MATLAB). Furthermore caveats of the measure are discussed along with it's relation to phase opposition measures.

• Asko, Olgerta; Blenkmann, Alejandro Omar; Leske, Sabine Liliana; Foldal, Maja Dyhre; Llorens, Ana?s & Funderud, Ingrid [Vis alle 10 forfattere av denne artikkelen] (2022). Altered hierarchical auditory predictive processing after lesions to the orbitofrontal cortex. Vis sammendrag

  In this study, we tested the causal involvement of the OFC in noticing breaches of predictions (i.e., PEs) at different hierarchical levels of task structural complexity. With this aim, we examined the event-related potentials (ERPs) of patients with focal OFC lesions and healthy adults while performing an auditory local-global oddball paradigm. Altogether, we found that after OFC damage, low-level PEs (i.e., processing of stimuli that are unpredicted at the local level) and combined low- and high-level PEs (i.e., processing of stimuli that are unpredicted at both the local and global level) were impacted. However, the processing of standard tones was not affected. We conclude that the OFC may contribute to a top-down process that modulates the deviance detection system in the primary auditory cortices, and may be involved in connecting PEs at lower hierarchical areas with predictions at higher areas. The study sheds new light on the poorly explored deficits of hierarchical auditory prediction in patients with damaged OFC.

• Volehaugen, Vegard; Leske, Sabine Liliana; Endestad, Tor; Solbakk, Anne-Kristin & Blenkmann, Alejandro Omar (2022). Violation of rule-based auditory patterns is detected independently of attention.
• Blenkmann, Alejandro Omar; Solbakk, Anne-Kristin; Leske, Sabine Liliana; Llorens, Ana?s; Funderud, Ingrid & Collavini, Santiago [Vis alle 13 forfattere av denne artikkelen] (2022). Human brain network involved in auditory deviance detection. An intracranial EEG study.
• Danielsen, Anne & Leske, Sabine Liliana (2022). How the brain tracks the precision of a beat bin - musical, behavioral and neurophysiological perspectives. Vis sammendrag

  The internal beat or pulse in the listener is not a single point in time, but has a shape and a width and can be described via a probability distribution. This phenomenon has been conceptualized in the beat bin thoery (Danielsen 2010). The internal beat bin of the listener varies systematically with the precision needed in the given musical or sonic context. Anne and Sabine will present behavioral evidence for this phenomenon and a first attempt to reveal the underlying neural mechanism behind the flexible adaptation to the precision of the current beat bin context. They will present effects of acoustic factors on the perceptual center and the beat bin, as well as preliminary results on how neural oscillatory activity might represent a neural mechanism behind this phenomenon.

• Danielsen, Anne; C?mara, Guilherme Schmidt; Lartillot, Olivier; Leske, Sabine Liliana & Spiech, Connor (2022). Musical rhythm. Behavioural, computational and neurophysiological perspectives.
• Funderud, Ingrid; Danielsen, Anne; Endestad, Tor; Jensenius, Alexander Refsum; Leske, Sabine Liliana & Solbakk, Anne-Kristin (2021). Improving working memory in patents with epilepsy by rhythmic sounds.
• Foldal, Maja Dyhre; Leske, Sabine Liliana; Blenkmann, Alejandro Omar; Endestad, Tor & Solbakk, Anne-Kristin (2021). Attentional modulation of alpha- and beta oscillations during perception of auditory rhythms.
• Solbakk, Anne-Kristin; Leske, Sabine Liliana; Lubell, James Isaac; Blenkmann, Alejandro Omar; Llorens, Anais & Funderud, Ingrid [Vis alle 13 forfattere av denne artikkelen] (2021). Auditory prediction and prediction error in self-generated tones.
• Blenkmann, Alejandro Omar; Solbakk, Anne-Kristin; Lubell, James; Leske, Sabine Liliana; Llorens, Ana?s & Funderud, Ingrid [Vis alle 14 forfattere av denne artikkelen] (2019). Human brain network involved in auditory deviance detection: Evidence from intracranial EEG recordings. Vis sammendrag

  The neural network underlying human auditory deviance detection is not fully understood. To address this, we recorded intracranial EEG from 22 adult patients with drug resistant epilepsy undergoing presurgical monitoring who had depth electrodes implanted in all brain lobes (1193 channels in total). Patients passively heard a stream of bilaterally presented tones while reading. We used the Optimum-1 paradigm, that consisted of 300 standard tones interleaved with 300 randomly presented deviant tones per block. Patients completed between 3 to 10 blocks. Deviant tones differed from standards in: 1) intensity (louder or softer), 2) frequency (higher or lower), 3) sound source location (right or left), 4) a shorter duration, or 5) a silent gap in the middle of the tone (N??t?nen et al., 2004). Electrode coordinates were obtained from coregistered MRI and CT images using iElectrodes toolbox (Blenkmann et al., 2017). Channels were bipolar referenced and high frequency band activity (HFA) analytic amplitude signal was obtained using the Hilbert transform (75-145 Hz). Compared to the baseline period, significant HFA responses to tones in general were observed in 31% of the channels. We used an ANOVA to quantify the HFA response variance across trials that could be explained by the different factors of the stimuli: Intensity, Laterality, Frequency, Duration and Gap. We estimated the amount of explained variance by using ?2 (Siegel et al., 2015). Eighteen % of the channels showed a significant increase of the condition-specific explained variance. Some channels showed condition-specific activations to one particular deviant, while others showed activations to a combination of two or more deviants. The channels showing responses to tones in general and condition-specific effects were mostly observed bilaterally in temporal cortex. Frontal, anterior cingulate, and parietal cortices were also involved to a lesser extent. Our results, in line with the predictive coding framework, reveal that a distributed brain network is involved in auditory processing and deviance detection.

• Blenkmann, Alejandro Omar; Solbakk, Anne-Kristin; Lubell, James; Leske, Sabine Liliana; Llorens, Ana?s & Funderud, Ingrid [Vis alle 14 forfattere av denne artikkelen] (2019). Human brain network involved in auditory deviance detection: Evidence from intracranial EEG recordings.
• Leske, Sabine Liliana; Lubell, James Isaac; Blenkmann, Alejandro Omar; Llorens, Ana?s; Funderud, Ingrid & Foldal, Maja Dyhre [Vis alle 13 forfattere av denne artikkelen] (2019). Auditory prediction and prediction error in self-generated tones.
• Leske, Sabine Liliana; Lubell, James; Blenkmann, Alejandro Omar; Llorens, Ana?s; Funderud, Ingrid & Foldal, Maja Dyhre [Vis alle 13 forfattere av denne artikkelen] (2019). Action-based auditory predictions. Vis sammendrag

  Sensory consequences of actions are predicted by the brain via an internal forward model to prepare sensory cortical areas, referred to as motor prediction. In a similar vein, the predictive coding framework suggests that perception is based on internal models making predictions about sensory events, based on statistical probabilities of the stimuli. In the current study we investigated action-based sensory predictions. We used a self-paced, two-choice random generation task, infrequently inducing deviant outcomes of voluntary action. Participants repeatedly pressed a right and a left button normatively associated with a 70 ms long 1 kHz and 2 kHz tone, respectively. Occasional deviants occurred, inverting the learned button-tone association. Participants were instructed that their button presses should be random, at a regular but self-paced tempo of one press per 1-2 s, and that they should press both buttons with equal probability. They were informed that the tones are task-irrelevant. We used intracranial EEG (iEEG) data recorded from 10 adult patients with electrodes localized in frontal and temporal lobes. The patients had drug resistant epilepsy and were undergoing presurgical monitoring via implanted stereotactic electrodes. Electrode coordinates and anatomical labels were obtained from coregistered MRI and CT images using iElectrodes toolbox. Initial results indicate that violations of action intentions modulated high frequency band activity (HFA, 75-145 Hz) in distributed brain regions including temporal and prefrontal cortices.

• Westner, Britta; Andersen, Lau M?ller; Blenkmann, Alejandro Omar & Leske, Sabine Liliana (2019). RITMO International EEG FieldTrip workshop, Lectures and Hands-on sessions .
• Leske, Sabine Liliana (2019). Oscillations and their functional relevance and Experimental design issues in EEG studies investigating oscillations.

Se alle arbeider i Cristin