L?reb?ker:
1. Branden and Tooze ?Introduction to protein structure', 2. utgave (1999)
2. Voet and Voet ?Biochemistry', 2. utgave (1995)
3. Wolfram Saenger ?Principles of Nucleic Acid Structure' (1984)
[Generell strukturkjemi dekkes av forelesningene. Vil ikke v?re grunnlag for direkte eksaminasjon, men sentrale begreper forutsettes kjent]
Branden and Tooze
Kap. 1. The building blocks 1-12
Kap. 2. Motifs of Protein Structure 12-33
Kap. 3. Alpha-Domain Structures 35-45
Kap. 4. Alpha/Beta Structures 47-64
Kap. 5. Beta Structures 67-87
Kap. 6. Folding and Flexibility 89-105
Kap. 8. DNA Recognition in Procaryotes by Helix-Turn-Helix Motif 129-141
Kap. 11. An Example of Enzyme Catalysis: Serine Proteinases 205-220
Kap. 12. Membrane Proteins 223-248
Kap. 14. Fibrous Proteins 283-298
Kap. 15. Recognition of Foreign Molecules by the Immune Systems 299-321
Kap. 16. The Structure of Spherical Viruses 325-338
Voet & Voet
Noen av kapitlene nedenfor er supplerende stoff/overlapp med Br?ndèn & Tooze. (Det kan v?re nyttig ? lese det samme stoffet med en annen innfallsvinkel.)
Kap. 4. Amino acids
- 1. The amino acids of proteins 56-62
- 2. Optical activity 62-67
- 3. ?Nonstandard Amino Acids 67-68
- A. Amino Acid Derivatives in Proteins
Kap. 7. Three-Dimentional Structures Of Proteins
- 1. Secondary Structures 141-153
- 2. Fibrous Proteins 153-162
Kap. 8. Protein Folding, Dynamics and Structural Evolution
- 1. Protein Folding 191-205
Kap. 9. Hemoglobin: Protein Function in Microcosm
- 1. Hemoglobin Function 216-217 (A. Heme)
- 2. Structure and Mechanism 223-231 (A. Structure of Myoglobin, B. Structure of Hemoglobin, C. Mechanism of Oxygen-Binding Cooperativity)
- 3. Abnormal Hemoglobins 235-241 (A. Molecular Pathology of HemoglobinB. Molecular Basis of Sickle-Cell Anemia)
Kap. 10. Sugars and Polysaccharides
- 1. Monosaccharides 253-258
- 2. Polysaccharides 258-265
- 3. Glycoproteins 266-274
Kap. 12. Enzymatic Catalysis
- 3. Serine proteases 389-398 (A. Kinetic and catalytic groups, B. X-Ray structures, C. Catalytic Mechanism, D. Testing the catalytic mechanism)
Kap. 28. Nucleic Acid Structures and Manipulation
- 1. Chemical structure and base composition 849-850
- 2. Double helical structures 850-862
- 3. Forces stabilizing nucleic acid structures 862-870
- 5. Supercoiled DNA 873-882
Kap. 29. Transcription
- 1. The role of RNA in protein synthesis 916-919
- 3. Control of transcription in prokaryotes 935-938 (D. Sequence-specific Protein-DNA Interactions)
Kap. 30. Translation
- 2. tRNA and its aminoacylation 967-971
- 3. Ribosomes 981-989 (A. Ribosome Structure)
Kap. 32. Viruses: Paradigms For Cellular Functions
- 1. Tobacco Mosaic Virus 1076-1081
- 2. Spherical Viruses 1081-1089
- 4. Influenza virus 1105-1113
Kap. 33. Eucaryotic gene expression
- 1. Chromosome Structure 1124-1133
Saenger
Kap. 15. tRNA - A Treasury of Sterochemical Information 331-349
Kap. 16. Intercalation 350-359
Kap. 19. Higher Organization of DNA 436-449
Totalt ca. 350 sider (overlapp ikke inkludert)