Course leader: Akhtar Hussain
Course Committee: Akhtar Hussain (AH) Atle Fretheim (AF), Lien Diep (LD), Institute for Health and Society Department of General Practice and Community Medicine.
Location: Fredrik Holts Hus, Room 218, Oslo University Hospital Ullevål (Ullevål sykehus). Address: Kirkeveien 166, 0450 Oslo.
Programme
Monday 07. March 2011
09.00 –09.45 Registration & Course introduction (AH & AF)
10.00 –10.45 Evidence Based Medicine (EBM) Concepts - Appraisal of Literature and Concepts of Systematic Review (AF)
11.00 –11.45: Concepts of Research Design (AH)
11.45 13.00 Lunch
13.00 –13.45 Undertaking a systematic review (AF)
14.00 –14.45 Appraising systematic Reviews (AF)
15.00 –15.45: Group work: Critical appraisal of a systematic review. Division into groups and assignment of group work (systematic review to assess)
Tuesday 08. March 2011
09.00 –10.45 Research design in intervention studies. Methods and types of clinical trials: uncontrolled trials, historical controls, concurrent non-randomized controls, randomized clinical trials cross over trials (AH)
11.00 –11.45 Diagnosis and its challenges in intervention studies, sensitivity, specificity (PPV and NPV) Agreement and kappa score. Measuring attributable risk for intervention/preventive measures. (AH)
11.45 –13.00 Lunch
13.00 –14.45 Group work on critical appraisal of systematic review continued from the day before (AF)
15.00 –15.45 Presentation and discussion of results of critical appraisal of systematic review (AF)
Wednesday 09. March 2011
09.00 – 09.45 What evidence is evidence? Evidence based medicine (AF)
10.00 –10.45 The case of an intervention study for changes in lifestyle (Bangladesh, Norway)
11.00 –11.45 The case of vaccine trials: An efficiacy trial of meningococcal B vaccine in Norwegian teenagers (Gunnar Bjune)
12.00 -13.00 Lunch
13.00 –13.45 Research Confounding and Bias, Sample Selection & sample size (AH)
14.00 –14.45 Finalize research Protocol
15.00 Presentation of Intervention Protocols
Thursday 10. March 2011
Responsible: Lien Diep
Mathematical models for the analysis of cohort studies and intervention outcomes (Lien)
09.00 Summary statistics, presenting data as graphs and tables.
10.00 Data lab.
12.00 Lunch
13.00 Odds ratio and relative risk revisited. Uncertainties and tests
15.00 Data lab.
16.00 End
Friday 11. March 2011
Responsible: Lien Diep
09.00 Logistic regression: confounding and interaction
12.00 Lunch
13.00 Data-lab: Logistic regression and test
15.00 Evaluation
16.00 End
Course literature:
Stuart J Pocock, Clinical Trials, Jekel James F: Epidemiology, biostatistics and preventive medicine (2nd edition).
Altman: Practical statistics for Medical Research. Evidence- Based Medicine (look for latest edition), Churchill Livingstone