Teaching plan

Teaching facilities:

The course takes place in Domus Medica (DM) and Domus Odontologica (DO) at the University of Oslo.

Teachers:

Professor Odd O. Aalen, Department of Biostatistics, IMB (Responsible for the course)

Associate professor Bettina Kulle Andreassen, Epi-gen, Ahus, UiO

Associate professor Birgitte Freiesleben de Blasio, Department of Biostatistics, IMB

Postdoc Jon Michael Gran, Department of Biostatistics, IMB

Research Fellow Morten Valberg

Monday 5. September:

08.30-09.00: Registration. (Outside Lille Auditorium in Domus Medica)

Location: GA02 A1.1001 Auditorium, DO

09.00-11.45: Data and descriptive statistics. (Aalen).

Literature: Aalen chap. 1 og 2, Kirkwood and Sterne chap. 3 and 4

11.45-12.30: Lunch break

Location: GA01 0183 PC-stue uetg. DM

12.30-13.45: Exercises: Introduction to SPSS

Exercises: 1 and 2 in the exercise booklet (Aalen)

Location: GA02 A1.1001 Auditorium, DO

14.00-15.45: Basic concepts of probability.(Aalen).

Literature: Aalen chap. 3.1-3.7. Kirkwood and Sterne chap. 14

Tuesday 6. September:

Location: GA02 A1.1001 Auditorium, DO

08.30-09.15: Bayes law. Sensitivity, specificity.(Aalen). Literature: Aalen chap. 3.9 and 3.10, Kirkwood and Sterne chap. 36.2

09.30-11.00: Binomial distribution. (Aalen).

Literature: Aalen chap. 4, Kirkwood and Sterne section 15.1 and 15.2

11.15-12.15: Exercises: 9 and 12 in the exercise booklet. (Aalen)

12.15-13.15: Lunch break

13.15-14.00: The normal distribution. (Andreassen). Literature: Aalen chap. 5, Kirkwood and Sterne chap. 5

14.15-15.00: Exercises. Exercise 14 in the exercise booklet. (Andreassen)

15.15-15.45: Discussion of exercises. (Andreassen)

Wednesday 7. September:

Location: GA02 A1.1004 seminarrom, DO

08.30-10.45: Introduction to hypothesis testing and confidence intervals. One-sample Student¡¯s test and conf. interval. (Andreassen).

Literature: Aalen chap. 8.1-8.5, Kirkwood and Sterne chap. 4, 6 and 7

Location: GA01 2170B PC-stue 2.etasje DM

11.00-12.00: Exercises. Exercise 13 in the exercise booklet. (Andreassen)

12.00-12.45: Lunch break

Location: GA02 A1.1004 seminarrom, DO

12.45-14.15: Two sample Student¡¯s test and confidence interval. (Andreassen).

Literature: Aalen chap. 8.6 og 8.7, Kirkwood and Sterne chap. 7

Location: GA01 2170B PC-stue 2.etasje DM

14.15-15.45: Exercises. Exercise 15 in the exercise booklet. (Andreassen)

Thursday 8. September:

Location: GA02 A1.1001 Auditorium, DO

08.30-11.15: Transformations. Non-parametric methods. (Gran).

Literature: Aalen chap. 8.8, Kirkwood and Sterne chap. 13 and 30.2

Location: GA01 2170B PC-stue 2.etasje DM

11.15-12.15: Exercises. Altman 9.2 and 9.4 and exercise 4 (all in the booklet). (Gran, Aalen)

12.15-13.00: Lunch break

Location: GA02 A1.1001 Auditorium, DO

13.00-14.30: Regression analysis, correlation.(Aalen).

Literature: Aalen chap. 11.1-11.3, Kirkwood and Sterne chap. 10

Location: GA01 2170B PC-stue 2.etasje DM

14.45-15.45: Exercises.(Gran, Aalen)

3 and 7 in the exercise booklet

Exercises for the intervening period:

You should read through the material from the first period and do the following exercises: 8, 10 and 11 in the exercise booklet We shall go through the exercises at the beginning of the next period.

Monday 19. September:

Location: GA02 A1.1001 Auditorium, DO

08.30-09.30: Discussion of the exercises from the intervening period. (Aalen)

09.45-11.15: Regression analysis cont., multiple regression. (Aalen).

Literature: Aalen chap. 11.4-11.6, Kirkwood and Sterne chap. 11 and 12

Location: GA01 0183 PC-stue uetg. DM

11.30-12.30: Exercises. (Gran, Aalen)

Exercises: Altman 11.2 + 18 in exercise booklet.

12.30-13.15: Lunch break

Location: GA02 A1.1001 Auditorium, DO

13.15-15.00: Some more about regression. Confounding. Interaction. (Aalen).

Literature: Kirkwood and Sterne chap. 38

Tuesday 20. September:

Location: GA02 A1.1001 Auditorium, DO

08.30-10.15: Statistical analysis of proportions. Odds ratio, relative risk etc.(Valberg).

Literature: Aalen chap. 6.1-6.4, Kirkwood and Sterne chap. 15 and 16

10.30-11.30: Exercises. (Valberg).

Exercises: 16 and 17 in the booklet

11.30-12.00: Discussion of exercises

12.00-12.45: Lunch break

12.45-14.15: Analyzing tables (chi squared, exact and Monte Carlo tests). (Valberg).

Literature: Aalen chap. 6.5, Kirkwood and Sterne chap. 17

Location: GA01 0183 PC-stue uetg. DM

14.30-15.30: Exercises. (Valberg)

Exercises: Altman 10.1a, 10.3, 10.7 (see Exercise booklet).

Wednesday 21. September:

Location: GA02 A1.1001 Auditorium, DO

08.30-09.30: Epidemiologic design and basic concepts. (Aalen)

09.45-11.30: Principles for organizing clinical trials. (Aalen).

Literature: Aalen chap. 9 og 10, Kirkwood and Sterne chap. 32 and 34

11.30-12.15: Lunch break

Location: GA02 A1.1001 Auditorium, DO

12.15-14.00: Sample size and power.(de Blasio).

Literature: Aalen chap. 9.6, Kirkwood and Sterne kap. 35

Location: GA02 A1.1001 Auditorium, DO

14.15-15.45: Exercises. (de Blasio, Aalen) - GA01 2228C, GA01 2228B, GA01 2227B, GA01 2227A, DM

Exercise 19, 20 and/or 21 from booklet

Thursday 22. September:

Location: GA02 A1.1001 Auditorium, DO

08.30-10.45: Survival analysis. (Gran).

Literature: Aalen chap. 13, Kirkwood and Sterne chap. 26

Location: GA01 0183 PC-stue uetg. DM

11.00-12.15: Exercises. (Gran)

Exercises: 5 and 6 from booklet

12.15-13.00: Lunch break

Location: GA02 A1.1001 Auditorium, DO

13.00-14.00: Limitations of statistics. Causality. (Aalen).

Literature: Aalen chap. 14.

14.00-14.45: Summary. (Aalen)

Course exam:

A take home exam will be handed out at the end of the course. This should be solved at home and then returned within a specified deadline.